What are the most common symptoms of mesothelioma? The first symptoms of mesothelioma include chest or abdominal pain, swelling and shortness of breath, depending on the location of the cancer. Because the signs in the early stage can be mild, doctors often confuse them with normal aches and pains or symptoms of less serious illnesses. The best App that has collected the best information about cancer mesothelioma, Treatments, Cures and Natural Drinks to fight cancer, information about lawyers for mesothelioma and much more relevant information. Mesothelioma tumors begin as small nodules in the lining of the lungs or abdomen. The cancer does not cause symptoms until the tumors have grown and spread. This usually occurs around stages 3 and 4 of cancer, when tumors begin to press against the chest wall or abdominal cavity. Recognizing the symptoms of mesothelioma early in the development of cancer is almost impossible because the disease does not produce early symptoms to identify.